I use an X-52 Pro, no rudders (I wish), dual monitor setup. I use a Razer Kraken headset, and no webcam. Logitech G510 keyboard, Kensington mouse.
Computer is powered by an i5-4460 quadcore at 3.20GHz, 8gb of RAM (need to upgrade), and a GTX960.
X52 Driver/Profiler A lot of people crap on the drivers/profiler for the X52, but without it you lose a lot of functionality. I can create a different profile for different planes, and switch profiles without taking my hands off the throttle and stick. Multiple "shift" modifiers are usable with the software too.
Logitech G510 Software For the pretty colors.
GlovePIE This is a fun one. It can turn voice commands into keyboard presses. Feel like a boss when you call out "PLANE! AUTOSTART!" instead of pressing "s". Very robust, and fun.
AutoHotKey Turns keypresses into macros. VERY powerful, easy scripting language, can pretty much do anything, including custom GUI's.
PDF-Viewer Ditch Adobe for PDF's. Seriously. PDF-Viewer has OCR capabality, saves where you are in a document, and is much more lightweight. Overall muuuuuuuch better for your PDF's.
Greenshot Amazing screenshot utility. Can automagically upload to imgur, has an integrated editor, lets you select what part of the screen your screenshotting, all around amazing. Can be slower on slower comps, so YMMV.
Open Broadcaster Software Used for recording your screen and broadcasting to twitch.
Lightworks x64 Good video editor - definitely complicated, but worth it.
Mumble ... if you have to ask ...
Mouse Without Borders This one is useful if you have multiple Windows comps. It allows you to essentially use those other computers as another monitor. You can easily copy files from one comp to the other, only need one keyboard + mouse, and can hook up up to 4 computers.
Great for me when I'm running AI or whatever on other computers.
brief aside - I know a lot of you aren't SUPER dedicated to realism, but if you want to actually plot out a low-level mission realistically, you'd use the ONC/TPC and the PLU-6C to do it. The image linked above for the plotter has a transparent background, so it'd work great loading it up in GIMP or whatever to plan out your missions.